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Granz lived to be 83 and spent much of his last three decades in Europe.
However, approximately one-fourth of these patients can still have high risk for disease relapse after surgical resection.Herein, we summarize recent findings and discuss the potential value of mi RNAs as prognostic biomarkers for CRC.For mi RNA as a diagnostic marker and its therapeutic potential, readers can refer to recent reviews written by our group and others.Indeed, a global impairment of mi RNA has been described in various human cancers, including CRC.A spectrum of dysregulated mi RNAs was identified to be associated with CRC genesis, progression, and therapeutic response.We also reviewe the potential application of mi RNA-associated single-nucleotide polymorphisms as prognostic biomarkers for CRC, especially the mi RNA-associated polymorphism in the gene.
Last but not least, we discuss the microsatellite instability-related mi RNA candidates.
To see Norman Granz introducing “Jazz at the Philharmonic” on television in 1956, look below.
Accepted for publication 17 July 2014 Published 14 October 2014 Volume 2014:6 Pages 405—422 DOI https://doi.org/10.2147/CMAR.
CRC includes two major entities: colon cancer (CC), the malignance in the inner wall of the colon that constitutes two-thirds to three-quarters of all CRC cases; and rectal cancer (RC), defined as cancer located within 12 cm or less from the anal verge.
CRC is a global public health problem: it is the third most common cancer and the fourth leading cause of cancer-related deaths in the world, with an estimated incidence of 1.2 million new cases and a mortality of Currently, the clinicopathologic tumor staging based on the tumor–node–metastasis (TNM) system is the basic prognostic marker for CRC clinical outcomes.
He cancelled more than one concert in venues that tried to segregate audiences or refused to accord black musicians the same accommodations as whites, and he was known for paying black and white musicians equally and for putting his own safety on the line to assure their fair and equal treatment.